A systemic drug, disease, or poison reaches and has an effect on the whole of a body or a plant and not just one part of it.

A systemic problem or change is a basic one, experienced by the whole of an organization or a country and not just particular parts of it.

The current recession is the result of a systemic change within the structure of the country's economy. 目前的经济衰退是国家经济结构发生了根本性的变化所引起的。